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Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
- McEnaney, Kerry;
- Barton, Brenda;
- Lentucci, Claudia;
- Saluvan, Mehmet;
- Chang, Ana C;
- Hoch, Annmarie;
- Albert, Marisa;
- Shaheen, Tanzia;
- Kho, Alvin T;
- Thomas, Sanya;
- Chen, Jing;
- Murphy, Maimouna D;
- Cooney, Mitchell;
- Hayati, Arash Nemati;
- Bryant, Robert;
- Abraham, James;
- Presnell, Scott;
- Jancsyk, Tomasz;
- Maguire, Cole;
- Lee, Brian;
- Fourati, Slim;
- Esserman, Denise A;
- Guan, Leying;
- Gygi, Jeremy;
- Pawar, Shrikant;
- Brito, Anderson;
- Fragiadakis, Gabriela K;
- Patel, Ravi;
- Tebbutt, Scott J;
- Overton, James A;
- Vita, Randi;
- Westendorf, Kerstin;
- Thyagarajan, Rama V;
- Rousseau, Justin F;
- Wylie, Dennis;
- Triplett, Todd A;
- Kojic, Erna;
- Chinthrajah, Sharon;
- Ahuja, Neera;
- Rogers, Angela J;
- Artandi, Maja;
- Yendewa, George;
- Powell, Debra L;
- Kim, James N;
- Simmons, Brent;
- Goonewardene, I Michael;
- Smith, Cecilia M;
- Martens, Mark;
- Sherman, Amy C;
- Walsh, Stephen R;
- Issa, Nicolas C;
- Salehi-Rad, Ramin;
- Dela Cruz, Charles;
- Farhadian, Shelli;
- Iwasaki, Akiko;
- Ko, Albert I;
- Anderson, Evan J;
- Mehta, Aneesh K;
- Sevransky, Jonathan E;
- Leligdowicz, Aleksandra;
- Matthay, Michael A;
- Singer, Jonathan P;
- Kangelaris, Kirsten N;
- Hendrickson, Carolyn M;
- Krummel, Matthew F;
- Woodruff, Prescott G;
- Anderson, Matthew L;
- Guirgis, Faheem W;
- Drevets, Douglas A;
- Brown, Brent R;
- Siegel, Sarah AR;
- Lu, Zhengchun;
- Mosier, Jarrod;
- Kimura, Hiroki;
- Khor, Bernard;
- Rahman, Adeeb;
- Stadlbauer, Daniel;
- Dutta, Jayeeta;
- Gonzalez-Reiche, Ana Silvia;
- van de Guchte, Adriana;
- Carreño, Juan Manuel;
- Singh, Gagandeep;
- Raskin, Ariel;
- Tcheou, Johnstone;
- Bielak, Dominika;
- Kawabata, Hisaaki;
- Xie, Hui;
- Kelly, Geoffrey;
- Patel, Manishkumar;
- Nie, Kai;
- Yellin, Temima;
- Fried, Miriam;
- Sullivan, Leeba;
- Morris, Sara;
- Sieg, Scott;
- van Zalm, Patrick;
- Fatou, Benoit;
- Mendez, Kevin;
- Lasky-Su, Jessica;
- Hutton, Scott R;
- Michelotti, Greg;
- Wong, Kari;
- Jha, Meenakshi;
- Viode, Arthur;
- Kanarek, Naama;
- Petrova, Boryana;
- Zhao, Yujiao;
- Boddapati, Arun K;
- Tharp, Greg K;
- Pellegrini, Kathryn L;
- Beagle, Elizabeth;
- Cowan, David;
- Hamilton, Sydney;
- Ribeiro, Susan Pereira;
- Hodder, Thomas;
- Lee, Serena;
- Wilson, Michael R;
- Alvarenga, Bonny;
- Rajan, Jayant;
- Schroeder, Andrew W;
- Tsitsiklis, Alexandra;
- Mick, Eran;
- Guerrero, Yanedth Sanchez;
- Love, Christina;
- Maliskova, Lenka;
- Adkisson, Michael;
- Siles, Nadia;
- Geltman, Janelle;
- Hurley, Kerin;
- Saksena, Miti;
- Altman, Deena;
- Srivastava, Komal;
- Eaker, Lily Q;
- Bermúdez-González, Maria C;
- Beach, Katherine F;
- Sominsky, Levy A;
- Azad, Arman R;
- Mulder, Lubbertus CF;
- Kleiner, Giulio;
- Lee, Alexandra S;
- Do, Evan;
- Fernandes, Andrea;
- Manohar, Monali;
- Hagan, Thomas;
- Blish, Catherine A;
- Din, Hena Naz;
- Roque, Jonasel;
- Yang, Samuel;
- Sigal, Natalia;
- Chang, Iris;
- Tribout, Heather;
- Harris, Paul;
- Consolo, Mary;
- Connors, Jennifer;
- Bernui, Mariana;
- Kutzler, Michele A;
- Edwards, Carolyn;
- Lee, Edward;
- Lin, Edward;
- Croen, Brett;
- Semenza, Nicholas C;
- Rogowski, Brandon;
- Melnyk, Nataliya;
- Woloszczuk, Kyra;
- Cusimano, Gina;
- Bell, Mathew R;
- Furukawa, Sara;
- McLin, Renee;
- Schearer, Pamela;
- Sheidy, Julie;
- Tegos, George P;
- Nagle, Crystal;
- Smolen, Kinga;
- Desjardins, Michael;
- van Haren, Simon;
- Mitre, Xhoi;
- Cauley, Jessica;
- Li, Xiaofang;
- Tong, Alexandra;
- Evans, Bethany;
- Montesano, Christina;
- Licona, Jose Humberto;
- Krauss, Jonathan;
- Chang, Jun Bai Park;
- Izaguirre, Natalie;
- Rooks, Rebecca;
- Elashoff, David;
- Brook, Jenny;
- Ramires-Sanchez, Estefania;
- Llamas, Megan;
- Rivera, Adreanne;
- Perdomo, Claudia;
- Ward, Dawn C;
- Magyar, Clara E;
- Fulcher, Jennifer A;
- Pickering, Harry C;
- Sen, Subha;
- Chaudhary, Omkar;
- Coppi, Andreas;
- Fournier, John;
- Mohanty, Subhasis;
- Muenker, M Catherine;
- Nelson, Allison;
- Raddassi, Khadir;
- Rainone, Michael;
- Ruff, William E;
- Salahuddin, Syim;
- Schulz, Wade L;
- Vijayakumar, Pavithra;
- Wang, Haowei;
- Wunder, Elsio;
- Young, H Patrick;
- Rothman, Jessica;
- Konstorum, Anna;
- Chen, Ernie;
- Cotsapas, Chris;
- Grubaugh, Nathan D;
- Wang, Xiaomei;
- Xu, Leqi;
- Asashima, Hiromitsu;
- Bristow, Laurel;
- Hussaini, Laila;
- Hellmeister, Kieffer;
- Wimalasena, Sonia Tandon;
- Cheng, Andrew;
- Spainhour, Christine;
- Scherer, Erin M;
- Johnson, Brandi;
- Bechnak, Amer;
- Ciric, Caroline R;
- Hewitt, Lauren;
- Carter, Erin;
- Mcnair, Nina;
- Panganiban, Bernadine;
- Huerta, Christopher;
- Usher, Jacob;
- Vaysman, Tatyana;
- Holland, Steven M;
- Abe-Jones, Yumiko;
- Asthana, Saurabh;
- Beagle, Alexander;
- Bhide, Sharvari;
- Carrillo, Sidney A;
- Chak, Suzanna;
- Ghale, Rajani;
- Gonzalez, Ana;
- Jauregui, Alejandra;
- Jones, Norman;
- Lea, Tasha;
- Lee, Deanna;
- Lota, Raphael;
- Milush, Jeff;
- Nguyen, Viet;
- Pierce, Logan;
- Prasad, Priya A;
- Rao, Arjun;
- Samad, Bushra;
- Shaw, Cole;
- Sigman, Austin;
- Sinha, Pratik;
- Ward, Alyssa;
- Willmore, Andrew;
- Zhan, Jenny;
- Rashid, Sadeed;
- Rodriguez, Nicklaus;
- Tang, Kevin;
- Altamirano, Luz Torres;
- Betancourt, Legna;
- Curiel, Cindy;
- Sutter, Nicole;
- Paz, Maria Tercero;
- Tietje-Ulrich, Gayelan;
- Leroux, Carolyn;
- Thakur, Neeta;
- Vasquez, Joshua J;
- Santhosh, Lekshmi;
- Song, Li-Zhen;
- Nelson, Ebony;
- Moldawer, Lyle L;
- Borresen, Brittany;
- Roth-Manning, Brittney;
- Ungaro, Ricardo F;
- Oberhaus, Jordan;
- Booth, J Leland;
- Sinko, Lauren A;
- Brunton, Amanda;
- Sullivan, Peter E;
- Strnad, Matthew;
- Lyski, Zoe L;
- Coulter, Felicity J;
- Micheleti, Courtney;
- Conway, Michelle;
- Francisco, Dave;
- Molzahn, Allyson;
- Erickson, Heidi;
- Wilson, Connie Cathleen;
- Schunk, Ron;
- Sierra, Bianca;
- Hughes, Trina
- et al.
Published Web Location
https://doi.org/10.1038/s41467-023-44090-5Abstract
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.
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